AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn. 

AbbVie has an opening for a Sr. Scientist I within the ADC Platform Group at our Bioresearch Center in Worcester, MA. The ADC platform group within SMTPT (Small Molecule Therapeutics & Platform Technologies) collaborates with drug discovery project teams across all AbbVie therapeutic areas including Oncology and Immunology. The ideal candidate will effectively collaborate with chemists, biologists and pharmacologists to characterize large and small molecules for ADC development.
 
Key Responsibilities:

• Lead the design and execution of in vitro assays for screening of biologics, small molecules and antibody drug conjugates
• Reporter, cytokine release, cell killing and antibody internalization assays
• Lead the execution of 2D and 3D phenotypic screening 
• Lead the development of cell line generation to support SAR screening of siRNAs, small molecules and biologics
• Lipid transfection and lenti viral infections
• Lead the study design and implementation of mechanism of action studies of our lead candidates
• Gene expression analysis, protein analysis (surface and intracellular proteins)
• Work collaboratively with project teams to deliver targets across portfolio 
• Demonstrate scientific excellence, work ethic, and dedication to team and project goals
• Work collaboratively in a matrix with project teams and members of the Biologics Group to drive innovation and deliver novel therapies to patients
• Develop productive collaborations and communication with other groups across therapeutic areas

Qualifications:

• Bachelor’s degree in related discipline with typically 10+ years of experience, or Master's degree with typically 8+ years of experience, or PhD with typically 0+ years of experience. 
• Experienced in leading and executing study designs for screening antibodies, small molecules and siRNAs (reporter assays, proliferation and cytokine release) 
• Experience executing antibody internalization and siRNA loss of function studies is a plus
• Experience with transfections and generating transient and stable cell lines
• Experience with gain and loss of function studies
• Experience with designing siRNAs therapeutics for delivery to mammalian cells is a plus
• Experience culturing adherent, suspension and primary cells
• Proficiency in performing flow cytometry and western blot experiments
• Experience with performing qPCR and automated western blot analysis
• Experience working with high throughput laboratory workflows and instruments such MACsQuant, FACS Canto, Microbeta, Wes, Amnis Imagestream, Via7 (taqman) and Spectramax plate readers.
• Experience documenting experimental methods and results into BIOELN
• Ability to summarize and present results to project teams

Key AbbVie Competencies:

• Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance.
• Learns fast, grasps the “essence” and can change the course quickly where indicated.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

  
  

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

  
  

• This job is eligible to participate in our short-term incentive programs. ​

  
  

​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

​

​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html 

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html